Automated characterization of gene expression patterns with an atlas of the mouse brain

J P Carson; T Ju; C Thaller; J Warren; M Bello; I Kakadiaris; W Chiu; G Eichele

doi:10.1109/IEMBS.2004.1403829

Automated characterization of gene expression patterns with an atlas of the mouse brain

Conf Proc IEEE Eng Med Biol Soc. 2004:2004:2917-20. doi: 10.1109/IEMBS.2004.1403829.

Authors

J P Carson¹, T Ju, C Thaller, J Warren, M Bello, I Kakadiaris, W Chiu, G Eichele

Affiliation

¹ Graduate Program in Struct. & Comput. Biol. & Molecular Biophys., Nat. Center for Macromolecular Imaging, Houston, TX, USA.

PMID: 17270888
DOI: 10.1109/IEMBS.2004.1403829

Abstract

A spatio-temporal map of gene activity in the brain would be an important contribution to the understanding of brain development, disease, and function. Such a resource is now possible using high-throughput in situ hybridization, a method for transcriptome-wide acquisition of cellular resolution gene expression patterns in serial tissue sections. However, querying an enormous quantity of image data requires computational methods for describing and organizing gene expression patterns in a consistent manner. In addressing this, we have developed procedures for automated annotation of gene expression patterns in the postnatal mouse brain.