Brain Pathol. 1991 Jan;1(2):107-14.

Interaction of T lymphocytes with cerebral endothelial cells in vitro.

Wekerle H, Engelhardt B, Risau W, Meyermann R.

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Max-Planck-Institute for Psychiatry, Munich, Federal Republic of Germany.

Abstract

As a prerequisite of inflammatory lesion formation in (auto-)immune disease of the central nervous system, lymphocytes have to interact with brain endothelia. In recent years much progress has been made towards a better understanding of mechanisms and factors involved in organ specific homing of lymphocytes. Many lines of evidence indicate that T lymphocytes recognizing antigens which are exclusively beyond the blood-brain barrier cross this barrier only when they are in an activated state, irrespective of their antigen specificity. Antigen presentation by blood-brain barrier endothelia, however, may play a role in later stages of florid inflammation.

PMID:: 1727014; [PubMed - indexed for MEDLINE]

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