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Aliment Pharmacol Ther. 2007 Feb 1;25(3):257-64.

Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children.

Author information

  • 1The Second Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland. hania@ipgate.pl

Erratum in

  • Aliment Pharmacol Ther. 2009 Apr;29(7):800.

Abstract

BACKGROUND:

Saccharomyces boulardii is a non-pathogenic probiotic yeast considered useful against enteropathogens.

AIM:

To assess the effectiveness of S. boulardii in treating acute infectious diarrhoea in children.

METHODS:

The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and S. boulardii: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials were included.

RESULTS:

Five randomized-controlled trials (619 participants) met the inclusion criteria. Combined data from four randomized-controlled trials showed that S. boulardii significantly reduced the duration of diarrhoea compared with control. The pooled weighted mean difference was -1.1 days (95% CI: -1.3 to -0.8) with a fixed model and remained significant in a random effect model. Saccharomyces boulardii significantly reduced the risk of diarrhoea on days 3, 6 and 7. Also the risk of diarrhoea lasting >7 days was significantly reduced in the S. boulardii group vs. control group (1 RCT, n = 88, RR 0.25, 95% CI: 0.08-0.83; NNT 5, 95% CI: 3-20).

CONCLUSIONS:

There exists a moderate clinical benefit of S. boulardii therapy in otherwise healthy infants and children with acute gastroenteritis, mainly a shorter duration of diarrhoea. However, these results should be interpreted with caution due to methodological limitations of the included studies.

PMID:
17269987
[PubMed - indexed for MEDLINE]
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