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Dig Liver Dis. 2007 Mar;39(3):228-31. Epub 2007 Jan 30.

Do MYO9B genetic variants predispose to coeliac disease? An association study in a cohort of South Italian children.

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  • 1Department of Pediatrics F Fede, Second University of Naples, Via Luigi De Crecchio 2, 80138 Naples, Italy.

Abstract

BACKGROUND:

Coeliac disease is a complex disorder influenced by environmental and genetic factors. A genome wide linkage study identified the myosin IXB (MYO9B) as a gene possibly associated with coeliac disease. Recently, a Dutch study reported a strong association of a single SNP, rs 2305764, of MYO9B with coeliac disease. However, two successive studies carried out on British and Swedish/Norwegian cohorts reported lack of association of the MYO9B variant with coeliac disease.

AIMS:

The aim of the present study is to verify the effects of the MYO9B rs 2305764 polymorphism on disease risk in a Mediterranean population of coeliac children.

PATIENTS AND METHODS:

To address this issue, an association study was performed in 223 (127 females) Italian coeliac children and adolescents and in 600 controls.

RESULTS:

The allelic frequencies of the MYO9B rs 2305764 polymorphism found in our patients and in the population control were not statistically different (P=0.46).

CONCLUSION:

The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from Southern Italy. This is in accordance with the most recent reports. Ethnic differences or a false positive result might explain the discrepancy with the Dutch study.

PMID:
17267307
[PubMed - indexed for MEDLINE]
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