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Exp Toxicol Pathol. 2007 Apr;58(5):361-5. Epub 2007 Jan 30.

Studies on argyrophilic nucleolar organizer regions (AgNORs) in a spontaneous mammary gland ductal carcinoma of a captive rhesus monkey.

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  • 1Oswaldo Cruz Foundation, Center for Laboratory Animal Breeding, Department of Primatology, Av. Brasil, 4365 Manguinhos, 21040-900 Rio de Janeiro/RJ, Brazil.


A spontaneous mammary gland ductal carcinoma was diagnosed in a 13-year-old female captive rhesus monkey (Macaca mulatta). The expression of argyrophilic nucleolar organizer regions (AgNORs) was studied to investigate the correlation between the histologic invasiveness and cell proliferation activity assay for predicting the biologic behavior of this tumor type. The results of this study show that the AgNOR size in tumor cells reflect the degree of malignancy when compared with the pattern of peripheral blood lymphocytes of the same individual. This is the first study showing a significant AgNOR feature of a malignant breast tumor in a rhesus monkey and it longs to provide additional diagnostic tool in tumor pathology.

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