Proteomics is aimed to illuminate the expression and function pattern of global protein in given organism, tissue, cell or subcellular structure. And its technical platform consists of high thoughout protein separation and indentification technology combinated with bioinformatic technology. In many research fields, proteomic technology provided comprehensive, dynamic, and reticular proteome information critical for the understanding of the molecular mechanism of disease processes or life phenomena. As infection is one of the most basic etiological factors, the strategy and technology of proteomics would be very useful in isolation and identification of pathogen proteome, host immune cellular proteome, infection-related proteins, vaccine candidate antigens, biomarkers and drug target proteins, which would then obviously promote the processes of infection-related research, such as pathogen, host response, mechanism of infection as well as the prophylaxis, diagnosis, and therapy of infection.