-
- Comment in:
-
Nat Biotechnol. 2007 Feb;25(2):189-90.
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88.
Pel HJ,
de Winde JH,
Archer DB,
Dyer PS,
Hofmann G,
Schaap PJ,
Turner G,
de Vries RP,
Albang R,
Albermann K,
Andersen MR,
Bendtsen JD,
Benen JA,
van den Berg M,
Breestraat S,
Caddick MX,
Contreras R,
Cornell M,
Coutinho PM,
Danchin EG,
Debets AJ,
Dekker P,
van Dijck PW,
van Dijk A,
Dijkhuizen L,
Driessen AJ,
d'Enfert C,
Geysens S,
Goosen C,
Groot GS,
de Groot PW,
Guillemette T,
Henrissat B,
Herweijer M,
van den Hombergh JP,
van den Hondel CA,
van der Heijden RT,
van der Kaaij RM,
Klis FM,
Kools HJ,
Kubicek CP,
van Kuyk PA,
Lauber J,
Lu X,
van der Maarel MJ,
Meulenberg R,
Menke H,
Mortimer MA,
Nielsen J,
Oliver SG,
Olsthoorn M,
Pal K,
van Peij NN,
Ram AF,
Rinas U,
Roubos JA,
Sagt CM,
Schmoll M,
Sun J,
Ussery D,
Varga J,
Vervecken W,
van de Vondervoort PJ,
Wedler H,
Wösten HA,
Zeng AP,
van Ooyen AJ,
Visser J,
Stam H.
DSM Food Specialties, PO Box 1, 2600 MA Delft, The Netherlands.
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.
PMID: 17259976 [PubMed - indexed for MEDLINE]
-
Cited by 29 PubMed Central articles
-
Characterization of oxylipins and dioxygenase genes in the asexual fungus Aspergillus niger.
Wadman MW, de Vries RP, Kalkhove SI, Veldink GA, Vliegenthart JF.
BMC Microbiol. 2009 Mar 23; 9:59. Epub 2009 Mar 23.
[BMC Microbiol. 2009]
-
Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production.
Harris DM, van der Krogt ZA, Klaassen P, Raamsdonk LM, Hage S, van den Berg MA, Bovenberg RA, Pronk JT, Daran JM.
BMC Genomics. 2009 Feb 10; 10:75. Epub 2009 Feb 10.
[BMC Genomics. 2009]
-
Exploiting proteomic data for genome annotation and gene model validation in Aspergillus niger.
Wright JC, Sugden D, Francis-McIntyre S, Riba-Garcia I, Gaskell SJ, Grigoriev IV, Baker SE, Beynon RJ, Hubbard SJ.
BMC Genomics. 2009 Feb 4; 10:61. Epub 2009 Feb 4.
[BMC Genomics. 2009]
- » See all...