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    Nat Rev Immunol. 2007 Feb;7(2):118-30.

    Humanized mice in translational biomedical research.

    Shultz LD, Ishikawa F, Greiner DL.

    Source

    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. lds@jax.org

    Abstract

    The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

    PMID:
    17259968
    [PubMed - indexed for MEDLINE]

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