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Diabetes Care. 2007 May;30(5):1039-43. Epub 2007 Jan 26.

High-viscosity hydroxypropylmethylcellulose blunts postprandial glucose and insulin responses.

Author information

  • 1Provident Clinical Research, 1000 W. 1st St., Bloomington, IN 47403, USA. kmaki@providentcrc.com

Erratum in

  • Diabetes Care. 2008 Sep;31(9): 1922-3.

Abstract

OBJECTIVE:

High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation was to assess the influence of HV-HPMC on postprandial glucose and insulin responses in overweight and obese men and women.

RESEARCH DESIGN AND METHODS:

Participants were 31 overweight or obese men and women without diabetes who underwent three breakfast meal tests in random order, separated by > or = 72 h. Test meals containing 75 g carbohydrate plus 4 or 8 g HV-HPMC or control meals containing 8 g cellulose were delivered in a double-blind fashion.

RESULTS:

Peak glucose was significantly lower (P < 0.001) after both HV-HPMC-containing meals (7.4 mmol/l [4 g] and 7.4 mmol/l [8 g]) compared with the control meal (8.6 mmol/l). Peak insulin concentrations and the incremental areas for glucose and insulin from 0 to 120 min were also significantly reduced after both HV-HPMC doses versus control (all P < 0.01).

CONCLUSIONS:

These findings indicate that HV-HPMC consumption reduces postprandial glucose and insulin excursions, which may favorably alter risks for diabetes and cardiovascular disease.

PMID:
17259476
[PubMed - indexed for MEDLINE]
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