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1: Bioorg Med Chem Lett. 2007 Mar 15;17(6):1523-6. Epub 2007 Jan 13.Click here to read Links

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.

van Oeveren A, Pio BA, Tegley CM, Higuchi RI, Wu M, Jones TK, Marschke KB, Negro-Vilar A, Zhi L.

Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA.

A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.

PMID: 17257838 [PubMed - indexed for MEDLINE]

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