This article reports a selective review of biopsychosocial research on successful or healthy aging published in 2005 and 2006. We describe a number of studies that advance the understanding of the definitions, predictors, mechanisms, and potential interventions for successful aging. Successful aging is a multidimensional construct that awaits a standardized definition. A broad array of phenotypes beyond longevity has been examined, including neurocognition, subjective quality of life, and biological age. Considerable progress has been made toward understanding possible mechanisms of successful aging through translational research. Interventions to augment healthy lifestyles have great potential to enhance global healthy aging.