AIDS. 2007 Jan 30;21(3):377-9.

Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures.

La Sala GB, Pilotti E, Nicoli A, Pinelli S, Villani MT, Ronzi P, Zendri E, Re MC, Magnani G, Casoli C.

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Division of Obstetrics, Gynecology and Reproduction Medicine, ASMN Reggio Emilia, Italy.

Abstract

We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P < 0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.

PMID:: 17255749; [PubMed - indexed for MEDLINE]

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Dynamics of HIV viral load in blood and semen of patients under HAART: impact of...
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Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures.

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