AIDS. 2007 Jan 30;21(3):367-9.

Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients.

Martínez E, Arnaiz JA, Podzamczer D, Dalmau D, Ribera E, Domingo P, Knobel H, Leyes M, Pedrol E, Force L, de Lazzari E, Gatell JM.

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Hospital Clínic, Barcelona, Spain.

Abstract

Patients with sustained virological suppression on protease inhibitor (PI)-based therapy were randomly assigned to switch the PI to nevirapine (n = 155), efavirenz (n = 156), or abacavir (n = 149) and were followed for at least 3 years regardless of the discontinuation of assigned therapy. There was a higher probability of maintaining virological suppression after 3 years of follow-up with nevirapine or efavirenz than with abacavir. In contrast, abacavir showed a lower incidence of adverse effects leading to drug discontinuation.

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