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Schizophr Bull. 2007 May;33(3):665-72. Epub 2007 Jan 25.

North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research.

Author information

  • 1Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada. jean_addington@camh.net

Abstract

This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.

PMID:
17255119
[PubMed - indexed for MEDLINE]
PMCID:
PMC2526151
Free PMC Article
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