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Head Neck. 2007 Jun;29(6):550-8.

Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.

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  • 1Department of Otolaryngology-Head and Neck Surgery, Veterans Affairs Medical Center, University of California, San Francisco, California, USA. swang@ohns.ucsf.edu

Abstract

BACKGROUND:

The CD44 family of receptors includes multiple variant isoforms, some of which have been linked to tumor progression. The objective of this study was to investigate whether CD44 v3-containing isoforms are involved in head and neck squamous cell carcinoma (HNSCC) tumor progression.

METHODS:

Laboratory investigation utilizing HNSCC cell lines and clinical tissue specimens was performed.

RESULTS:

Investigation of 13 HNSCC cell lines revealed a diversity of CD44 isoform profiles, including expression of CD44 v3-containing isoforms. Two cell lines, HOC313 and MDA1483, were selected for further study based on their CD44 v3 expression profile. The HOC313 cell line, which highly expresses CD44 v3-containing isoforms, demonstrated hyaluronan-mediated CD44-dependent promotion of tumor cell growth and migration. Conditioned media from the HOC313 cell line also exhibited high matrix metalloproteinase expression on gelatin zymography. Immunohistochemical analysis of a series of metastatic HNSCC lymph nodes revealed CD44 overexpression as well as staining for CD44 v3-containing isoforms.

CONCLUSION:

CD44 v3-containing isoforms are associated with HNSCC growth, migration, and matrix metalloproteinase activity and can be identified in lymph node metastasis.

(c) 2007 Wiley Periodicals, Inc. Head Neck, 2007.

PMID:
17252589
[PubMed - indexed for MEDLINE]
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