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Eur J Neurol. 2007 Feb;14(2):224-7.

Post-traumatic spontaneous recurrent hypothermia: a variant of Shapiro's syndrome.

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  • 1Department of Neurology, Ghent University Hospital, Ghent, Belgium.


A 49-year-old man presented with episodic hypothermia many years after sustaining a contusional brain injury. Brain magnetic resonance imaging demonstrated the destruction of the anterior parts of the corpus callosum without hypothalamic lesions. Nevertheless, delayed hypothalamic dysfunction at the neurotransmitter level is the probable pathophysiological key factor. Clomipramine treatment was beneficial. This case expands the spectrum of Shapiro's syndrome.

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