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Pediatrics. 2007 Feb;119(2):e474-83. Epub 2007 Jan 22.

Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement.

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  • 1Department of Pediatric Pneumology and Immunology, Charite-Universit√§tsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. tilmann.kallinich@charite.de

Abstract

The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of introduction, etc), no standardized treatment recommendations have been established. In this work we review the available literature on colchicine use with respect to its indication, efficacy, mode of application, and safety in children and adolescents with familial Mediterranean fever. On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey.

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