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FEBS Lett. 2007 Feb 6;581(3):479-82. Epub 2007 Jan 16.

UCP2 is a mitochondrial transporter with an unusual very short half-life.

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  • 1CNRS-UPR 9078; Université Paris Descartes, Faculté de Médecine, site Necker, 75730 Paris Cedex 15, France.


This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30min, compared to 30h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.

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