Protein structure: evolutionary bridges to new fol...[Curr Biol. 2007]

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1: Curr Biol. 2007 Jan 23;17(2):R48-50. Links

Comment on:: Curr Biol. 2007 Jan 23;17(2):173-8.

Protein structure: evolutionary bridges to new folds.

Yeates TO.

UCLA Department of Chemistry and Biochemistry, 611 Charles Young Drive East, Los Angeles, California 90095-1569, USA. yeates@mbi.ucla.edu

The question of whether novel, structurally different protein folds might have arisen from existing ones is crucial to understanding protein evolution. Recent work on cysteine-rich domains in Hydra proteins illuminates how evolutionary transitions between dramatically different structures might occur.

PMID: 17240325 [PubMed - indexed for MEDLINE]

Continuous molecular evolution of protein-domain structures by single amino acid changes. [Curr Biol. 2007]
The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern. [J Mol Biol. 2005]
A structure-centric view of protein evolution, design, and adaptation. [Adv Enzymol Relat Areas Mol Biol. 2007]
Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation. [FEBS Lett. 2004]
Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall. [J Mol Biol. 2007]
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Protein structure: evolutionary bridges to new folds.

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