Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Peptides. 2007 Feb;28(2):480-3. Epub 2007 Jan 18.

Neuropeptide Y (NPY) in alcohol intake and dependence.

Author information

  • Laboratory of Clinical and Translational Studies, NIH/NIAAA, Building 10-CRC/Room 1-5330, 10 Center Drive, Bethesda, MD 20892-1108, USA. annika.thorsell@mail.nih.gov


Neuropeptide Y has a role in alcohol intake and dependence. NPY's effect on alcohol intake appears to be in part dependent on the individual's history of alcohol dependence. In models of high intake such as alcohol-preferring, selectively bred rat lines (e.g., the P-line and the HAD line), as well as in ethanol-vapor-exposed subjects, NPY modulates alcohol intake while leaving it unaffected during baseline conditions. The primary receptor subtype mediating NPY's effect on ethanol intake remains in question. The Y2-antagonist BIIE0246 significantly suppresses ethanol intake in an operant paradigm with a sensitization to the effect of BIIE0246 in vapor-exposed subjects. We propose the NPY system to be one of the most interesting target systems for the development of treatments for alcohol abuse and dependence.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk