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J Neuroimaging. 2007 Jan;17(1):74-7.

Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI.

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  • 1Department of Neurology, Neurology Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

BACKGROUND AND PURPOSE:

We sought to determine whether mid-sagittal intracranial area (ICA) is a valid surrogate of intracranial volume (ICV) when using retrospective data with relatively thick (6-7 mm) sagittal slices.

METHODS:

Data were retrospectively analyzed from 47 subjects who had two MRI scans taken at least nine months apart. Twenty-three subjects had manual segmentation of ICV on the T2-weighted sequence for comparison.

RESULTS:

Intraclass correlation coefficient (ICC) for intraobserver, interobserver, and intraobserver scan-rescan comparisons were 0.96, 0.97 and 0.95. Pearson correlation coefficients between ICV and ICA, averaging the cumulative 1, 2, 3, and 4 most midline slices, were 0.89, 0.94, 0.93, and 0.95. There was a significant marginal increase in explained variance of ICV by measuring two, rather than one, slices (P= 0.001).

CONCLUSIONS:

These data suggest that ICA, even measured without high-resolution imaging, is a reasonable substitute for ICV.

PMID:
17238873
[PubMed - indexed for MEDLINE]
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