Am J Hematol. 2007 Jun;82(6):489-92.

Complete remission of multiple myeloma after autoimmune hemolytic anemia: possible association with interferon-alpha.

Gesundheit B, Zelig O, Shapira MY, Ackerstein A, Avgil M, Or R.

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Department of Bone Marrow Transplantation, Cancer Immunotherapy and Immunobiology Research Center, Hadassah University Hospital, Jerusalem, Israel. gesund@hadassah.org.il

Abstract

A patient with multiple myeloma (MM) was being maintained on human recombinant interferon-alpha (INF-alpha) after VAD and autologous bone marrow transplantation (pretreated with melphalan). An episode of immune thrombocytopenia and (Coombs positive) autoimmune hemolytic anemia (AIHA) was noted while on maintenance INF-alpha, which remitted when it was withdrawn. Following this event, he achieved a state of stable disease that persists (more than 3 years) with no specific myeloma treatment. This sequence of events suggests a relationship between an immunological reaction induced by INF-alpha and the prolonged phase of stable disease.

PMID:: 17236186; [PubMed - indexed for MEDLINE]

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Complete remission of multiple myeloma after autoimmune hemolytic anemia: possible association with interferon-alpha.

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