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1: Phytother Res. 2007 May;21(5):427-33.Click here to read Links

In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease.

Conforti F, Statti GA, Tundis R, Loizzo MR, Menichini F.

Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy. filomena.conforti@unical.it

The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexane extract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes. The most abundant constituents were two monoterpenes: limonene and gamma-terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH test, beta-carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect. Copyright 2007 John Wiley & Sons, Ltd.

PMID: 17236166 [PubMed - indexed for MEDLINE]