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Cancer Res. 2007 Jan 15;67(2):429-32.

Systemic efficacy with oncolytic virus therapeutics: clinical proof-of-concept and future directions.

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  • 1Brain Tumor Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.


Oncolytic viruses that can destroy cancer cells have been engineered in a variety of ways with the aim of improving their selectivity and efficacy. Here, we review data from clinical investigations of these virotherapeutic agents, specifically those that have shown systemic efficacy: vaccinia, measles, mumps, viruses, Newcastle disease virus, and reovirus. Further directions for optimizing i.v. delivery and efficacy are discussed.

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