Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Biotechnol. 2007 Feb;18(1):17-25. Epub 2007 Jan 17.

Fluorescence imaging in vivo: recent advances.

Author information

  • 1Molecular Imaging Program at Stanford, Department of Radiology & Bio-X Program, Cancer Biology Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305-5484, USA. jrao@stanford.edu <jrao@stanford.edu>

Abstract

In vivo fluorescence imaging uses a sensitive camera to detect fluorescence emission from fluorophores in whole-body living small animals. To overcome the photon attenuation in living tissue, fluorophores with long emission at the near-infrared (NIR) region are generally preferred, including widely used small indocarbocyanine dyes. The list of NIR probes continues to grow with the recent addition of fluorescent organic, inorganic and biological nanoparticles. Recent advances in imaging strategies and reporter techniques for in vivo fluorescence imaging include novel approaches to improve the specificity and affinity of the probes and to modulate and amplify the signal at target sites for enhanced sensitivity. Further emerging developments are aiming to achieve high-resolution, multimodality and lifetime-based in vivo fluorescence imaging.

PMID:
17234399
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk