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Mov Disord. 2007 Feb 15;22(3):417-20.

Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.

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  • 1Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico.


We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-epsilon4 allele and APOE epsilon4/epsilon3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).

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