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J Invest Dermatol. 2007 Feb;127(2):262-3.

Human keratinocyte Toll-like receptors promote distinct immune responses.

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  • 1Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.


It has been well established that Toll-like receptors (TLRs) are expressed by keratinocytes and respond to their respective ligands to initiate immune responses. However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen.

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