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Handb Exp Pharmacol. 2007;(179):379-408.

Know thy neighbor: a survey of diseases and complex syndromes that map to chromosomal regions encoding TRP channels.

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  • 1Transmembrane Signaling Group, Laboratory of Signal Transduction, Division of Intramural Research, National Institutes of Environmental Health Sciences, NIH, DHHS, Building 101, Room A214, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.


On the basis of their ever-expanding roles, not only in sensory signaling but also in a plethora of other, often Ca(2+)-mediated actions in cell and whole body homeostasis, it is suggested that mutations in TRP channel genes not only cause disease states but also contribute in more subtle ways to simple and complex diseases. A survey is therefore presented of diseases and syndromes that map to one or multiple chromosomal loci containing TRP channel genes. A visual map of the chromosomal locations of TRP channel genes in man and mouse is also presented.

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