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J Struct Biol. 2007 May;158(2):196-204. Epub 2006 Nov 21.

Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering.

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  • 1The Burnham Institute of Medical Research, La Jolla, CA 92037, USA.


A simple, fast and efficient noise-reduction protocol for three-dimensional electron tomographic reconstructions of biological material is presented. The approach is based on iterative application of median filtering and shows promise for automatic noise reduction as a pre-processor for automated data analysis tools which aim at segmentation, feature extraction and pattern recognition. The application of this algorithm produces encouraging results for a wide variety of experimental and synthetic electron tomographic reconstructions.

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