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Toxicon. 2007 Mar 15;49(4):550-60. Epub 2006 Dec 5.

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.

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  • 1Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, Building 35, 3B 211, NINDS, NIH, Bethesda, MD 20892, USA.

Abstract

Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.

PMID:
17224168
[PubMed - indexed for MEDLINE]
PMCID:
PMC1868498
Free PMC Article
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