Cancer Cell. 2007 Jan;11(1):1-3.

Rb loss causes cancer by driving mitosis mad.

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Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA. vandeursen.jan@mayo.edu

Abstract

Aneuploidy is a hallmark of most human cancers, but whether it is a cause or a consequence of cellular transformation remains a subject of debate. The spindle checkpoint functions to prevent aneuploidy and plays a central role in this discussion. The checkpoint gene Mad2 is activated by E2F1 and overexpressed in cells lacking a functional Rb pathway. In this issue of Cancer Cell, Sotillo and coworkers report that Mad2 overexpression leads to chromosomal instability and tumorigenesis, indicating that Mad2 contributes to cancer development after Rb mutation. In a second paper, Weaver et al. report that aneuploidy has both tumor-promoting and -suppressing properties.

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Cancer Cell. 2007 Jan;11(1):9-23.

PMID:: 17222786; [PubMed - indexed for MEDLINE]

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