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1: Mol Cell Endocrinol. 2007 Feb;265-266:138-42. Epub 2007 Jan 11.Click here to read Click here to read Links

GPR30: A G protein-coupled receptor for estrogen.

Prossnitz ER, Arterburn JB, Sklar LA.

Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. eprossnitz@salud.unm.edu

Estrogen is a critical steroid in human physiology exerting its effect both at the transcriptional level as well as at the level of rapid intracellular signaling through second messengers. Many of estrogen's transcriptional effects have long been known to be mediated through classical nuclear steroid receptors but recent studies also demonstrate the existence of a 7-transmembrane G protein-coupled receptor, GPR30 that responds to estrogen with rapid cellular signaling. There is currently controversy over the ability of classical estrogen receptors to recapitulate GPR30-mediated signaling mechanisms and vice versa. This article will summarize recent literature and address the relationship between GPR30 and conventional estrogen receptor signaling.

PMID: 17222505 [PubMed - indexed for MEDLINE]

PMCID: PMC1847610

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