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Arch Immunol Ther Exp (Warsz). 2007 Jan-Feb;55(1):41-7.

Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors.

Author information

  • 1Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany.

Abstract

INTRODUCTION:

Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells.

MATERIALS AND METHODS:

Expression of IL-16 was analyzed by immunohistochemistry in human astrocytic brain tumors and the rat C6 glioblastoma tumor model. IL-16 was detected in both human astrocytic brain tumors and rat C6 glioma.

RESULTS:

Compared with human control brains, a significant increase in the percentages of parenchymal IL-16+ macrophages/microglia was observed already in grade II astrocytomas, indicating that IL-16+ immunostaining could be a descriptor of a macrophage/microglia subset in astrocytic brain tumors. A further increase was observed at the transition from grade II to III astrocytomas. This increase in IL-16 immunoreactivity correlated with WHO grades of human astrocytic brain tumors.

CONCLUSIONS:

Therefore, IL-16 might be a so far unknown factor in the regulation of the local inflammatory milieu of human and experimental astrocytomas.

PMID:
17221335
[PubMed - indexed for MEDLINE]
PMCID:
PMC3234149
Free PMC Article
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