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    Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14.

    Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.

    Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H.

    Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.

    'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

    PMID: 17220897 [PubMed - indexed for MEDLINE]

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