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Nat Methods. 2007 Feb;4(2):131-3. Epub 2007 Jan 14.

Transposon-tagged mutagenesis in the rat.

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  • 1Laboratory of Mammalian Genetics, Division of Genome Dynamics, Creative Research Initiative Sousei, Hokkaido University, North 10 West 8, Kita-ku, Sapporo 060-0810, Japan. kkitada@cast.hokudai.ac.jp


Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model.

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