Infect Immun. 2007 Mar;75(3):1537-9. Epub 2007 Jan 12.

Role of unsaturated fatty acid biosynthesis in virulence of Streptococcus mutans.

Fozo EM, Scott-Anne K, Koo H, Quivey RG Jr.

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Department of Microbiology and Immunology, Center for Oral Biology, Rochester, NY 14642, USA.

Abstract

An insertionally inactivated fabM strain of Streptococcus mutans does not produce unsaturated membrane fatty acids and is acid sensitive (E. M. Fozo and R. G. Quivey, Jr., J. Bacteriol. 186:4152-4158, 2004). In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than those observed in the wild-type strain.

PMID:: 17220314; [PubMed - indexed for MEDLINE]
PMCID: PMC1828593

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Research Support, N.I.H., Extramural

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Fatty Acids, Unsaturated

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