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Arch Virol. 2007;152(5):1035-44. Epub 2007 Jan 15.

Detection of two porcine circovirus type 2 genotypic groups in United States swine herds.

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  • 1Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa 50010, USA. acheung@nadc.ars.usda.gov


In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.

[PubMed - indexed for MEDLINE]
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