Cell Cycle. 2007 Jan 1;6(1):3-7. Epub 2007 Jan 9.

Phosphatase and feedback regulation of Raf-1 signaling.

Dhillon AS, von Kriegsheim A, Grindlay J, Kolch W.

Source

Signaling and Proteomics Group, Beatson Institute for Cancer Research, Glasgow, UK. A.Dhillon@beatson.gla.ac.uk

Abstract

The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events--relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling.

PMID:: 17218791; [PubMed - indexed for MEDLINE]

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