Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives

Br Med J. 1975 Nov 29;4(5995):496-8. doi: 10.1136/bmj.4.5995.496.

Abstract

A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive of focal nodular hyperplasia, while the remainder had the histological characteristics of a well-differentiated hepatocellular carcinoma. This is the first report of malignant transformation of a tumour in a patient taking oral contraceptives.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Hepatocellular / chemically induced*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery
  • Contraceptives, Oral / adverse effects*
  • Ethinyl Estradiol / adverse effects
  • Female
  • Hepatectomy
  • Humans
  • Liver Neoplasms / chemically induced*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery
  • Megestrol / adverse effects
  • Neoplasms, Multiple Primary / chemically induced*
  • Neoplasms, Multiple Primary / pathology
  • Neoplasms, Multiple Primary / surgery

Substances

  • Contraceptives, Oral
  • Ethinyl Estradiol
  • Megestrol