Display Settings:

Format

Send to:

Choose Destination
    Cell. 2007 Jan 12;128(1):20-1.

    Polo delivers a PICH to the kinetochore.

    Source

    Fox Chase Cancer Center, Philadelphia, PA 19083, USA. timothy.yen@fccc.edu

    Abstract

    In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase. These threads are thought to be catenated centromeric DNA. PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores and is proposed to regulate checkpoint signaling by monitoring tension at centromeres.

    PMID:
    17218250
    [PubMed - indexed for MEDLINE]

      Supplemental Content

      Icon for Elsevier Science

      Save items

      loading

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk