Curr Top Microbiol Immunol. 2007;313:49-71.

SUMO, the three Rs and cancer.

Seeler JS, Bischof O, Nacerddine K, Dejean A.

Source

Nuclear Organisation and Oncogenesis Unit, INSERM U.579, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris 15, France. seeler@pasteur.fr

Abstract

SUMO modification (sumoylation) plays important roles in nucleo-cytoplasmic transport, maintenance of sub-nuclear architecture, the regulation of gene expression and in DNA replication, repair and recombination. Here we review recent evidence for SUMO's role in protecting genomic integrity at both the chromosomal and the DNA level. Furthermore, the involvement of sumoylation and of specific SUMO targets in cancer is discussed.

PMID:: 17217038; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review SUMO: a regulator of gene expression and genome integrity. [Oncogene. 2004]
Review SUMO: a regulator of gene expression and genome integrity.
Müller S, Ledl A, Schmidt D. Oncogene. 2004 Mar 15; 23(11):1998-2008.
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis. [J Mol Histol. 2006]
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Moschos SJ, Mo YY. J Mol Histol. 2006 Sep; 37(5-7):309-19. Epub 2006 Jun 7.
Review Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties? [Trends Cell Biol. 2008]
Review Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
Palancade B, Doye V. Trends Cell Biol. 2008 Apr; 18(4):174-83. Epub 2008 Mar 3.
Review SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? [Genes Dev. 2004]
Review SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
Gill G. Genes Dev. 2004 Sep 1; 18(17):2046-59.
SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair. [Mol Cell Biol. 2006]
SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.
Yurchenko V, Xue Z, Sadofsky MJ. Mol Cell Biol. 2006 Mar; 26(5):1786-94.

See reviews... See all...

Cited by 10 PubMed Central articles

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. [PLoS Genet. 2012]
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
Wu X, Shi Z, Cui M, Han M, Ruvkun G. PLoS Genet. 2012 Mar; 8(3):e1002542. Epub 2012 Mar 8.
Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). [J Biol Chem. 2010]
Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).
Snow JW, Kim J, Currie CR, Xu J, Orkin SH. J Biol Chem. 2010 Sep 3; 285(36):28064-75. Epub 2010 Jun 28.
PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes. [J Biol Chem. 2010]
PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes.
Ryu H, Al-Ani G, Deckert K, Kirkpatrick D, Gygi SP, Dasso M, Azuma Y. J Biol Chem. 2010 May 7; 285(19):14415-23. Epub 2010 Mar 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

SUMO, the three Rs and cancer.
SUMO, the three Rs and cancer.
Curr Top Microbiol Immunol. 2007 ;313:49-71.

PubMed
Substance P- and calcitonin gene-related peptide immunoreactivity in primary aff...
Substance P- and calcitonin gene-related peptide immunoreactivity in primary afferent neurons of the cat's knee joint.
Neuroscience. 1991 ;45(1):185-93.

PubMed
[Clinical use of a new class of anticoagulant drugs: the direct thrombin inhibit...
[Clinical use of a new class of anticoagulant drugs: the direct thrombin inhibitors].
G Ital Cardiol (Rome). 2006 Nov ;7(11):739-46.

PubMed
Travel-related thrombosis: is this a problem?
Travel-related thrombosis: is this a problem?
Isr Med Assoc J. 2006 Dec ;8(12):859-61.

PubMed
The organization of serotonergic projections to cerebral cortex in primates: ret...
The organization of serotonergic projections to cerebral cortex in primates: retrograde transport studies.
Neuroscience. 1991 ;44(3):555-70.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: