Cancer Genet Cytogenet. 2007 Jan 15;172(2):158-64.

Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced variant of the t(11;14)(q13;q32) translocation in mantle cell lymphoma.

Sathanoori M, Shekhter-Levin S, Marks SM, Swerdlow SH.

Source

Pittsburgh Cytogenetics Laboratory, Magee-Womens Hospital, University of Pittsburgh Medical Center Health System, 300 Halket Street, Pittsburgh, PA 15213, USA.

Abstract

We report the case of a 62-year-old man who presented with splenomegaly, leukocytosis, anemia, and thrombocytopenia. Examination of the peripheral blood, bone marrow, and spleen revealed involvement by mantle cell lymphoma, with some blastoid features and an atypical phenotype. Spleen and bone marrow classical chromosome analysis followed by fluorescence in situ hybridization revealed a novel and unusual unbalanced variant of the t(11;14)(q13;q32) translocation, resulting in a complex derivative chromosome harboring the IGH/CCND1 fusion gene. This chromosome was designated as der(14)t(11;14)(q13;q32)t(11;14)(p11.1;p11.2).

PMID:: 17213026; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma. [Leukemia. 2004]
Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma.
Wlodarska I, Meeus P, Stul M, Thienpont L, Wouters E, Marcelis L, Demuynck H, Rummens JL, Madoe V, Hagemeijer A. Leukemia. 2004 Oct; 18(10):1705-10.
Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma. [Cancer Genet Cytogenet. 2007]
Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma.
Woroniecka R, Grygalewicz B, Pienkowska-Grela B, Rymkiewicz G, Konecki R, Swoboda P, Janik P. Cancer Genet Cytogenet. 2007 Jun; 175(2):154-8.
Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14. [J Clin Pathol. 2003]
Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14.
Aventín A, Nomdedéu J, Briones J, Espinosa I, Bordes R, Sierra J. J Clin Pathol. 2003 Oct; 56(10):798-800.
Review Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features. [Mod Pathol. 2002]
Review Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features.
Hao S, Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ. Mod Pathol. 2002 Dec; 15(12):1266-72.
Review B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia. [Br J Haematol. 2004]
Review B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia.
Ruchlemer R, Parry-Jones N, Brito-Babapulle V, Attolico I, Wotherspoon AC, Matutes E, Catovsky D. Br J Haematol. 2004 May; 125(3):330-6.

See reviews... See all...

Cited by 1 PubMed Central article

CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations. [Ann Lab Med. 2012]
CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations.
Seok Y, Kim J, Choi JR, Kim YR, Park SJ, Kim SJ, Song J, Lee KA. Ann Lab Med. 2012 Jan; 32(1):95-8. Epub 2011 Dec 20.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced varian...
Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced variant of the t(11;14)(q13;q32) translocation in mantle cell lymphoma.
Cancer Genet Cytogenet. 2007 Jan 15 ;172(2):158-64.

PubMed
High-resolution analysis of allelic imbalance in neuroblastoma cell lines by sin...
High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays.
Cancer Genet Cytogenet. 2007 Jan 15 ;172(2):127-38.

PubMed
Increasing resistance to ciprofloxacin and other antibiotics in Neisseria gonorr...
Increasing resistance to ciprofloxacin and other antibiotics in Neisseria gonorrhoeae from East Java and Papua, Indonesia, in 2004 - implications for treatment.
Int J STD AIDS. 2006 Dec ;17(12):810-2.

PubMed
The role of breakfast in nutrient intake of urban schoolchildren.
The role of breakfast in nutrient intake of urban schoolchildren.
Public Health Nutr. 2007 Jan ;10(1):55-8.

PubMed
Fast food for family meals: relationships with parent and adolescent food intake...
Fast food for family meals: relationships with parent and adolescent food intake, home food availability and weight status.
Public Health Nutr. 2007 Jan ;10(1):16-23.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: