Complement Ther Clin Pract. 2007 Feb;13(1):25-8. Epub 2006 Dec 13.

Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis.

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University of North Carolina at Charlotte, School of Nursing, 9201 University Blvd, Charlotte, NC 28223, USA. srhardin@email.uncc.edu

Abstract

Cat's claw (Uncaria tomentosa and Uncaria guianesis) is a medicinal plant from the Amazon commonly used to treat disorders such as arthritis, gastritis and osteoarthritis. The mechanism of cat's claw appears to be as an inhibitor of TNFalpha and antioxidant. Understanding the processes in osteoarthritis may facilitate and clarify the potential role of cat's claw as a complementary therapy to assist in the reduction of pro-inflammatory mediators and effectors. The clinical relevance of this therapy as a viable modality of intervention will be discussed.

PMID:: 17210508; [PubMed - indexed for MEDLINE]

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Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. [Inflamm Res. 2001]
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