Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cancer Biol. 2007 Apr;17(2):154-65. Epub 2006 Dec 15.

Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.

Author information

  • 1Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Abstract

Understanding and manipulating cell death pathways are critical to our ability to treat human degenerative diseases and cancer. The zebrafish Danio rerio, a common aquatic pet, has evolved as a powerful tool for the discovery of genes regulating cellular suicide both during normal vertebrate development and after genetic or environmental insult. In this review, we describe the techniques that can be applied to studying cell death in zebrafish as well as highlighting what has been discovered so far. Finally, we discuss future perspectives in the field and how they relate to human disease.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk