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Pediatr Pathol. 1991 Sep-Oct;11(5):737-49.

Childhood pulmonary blastoma: a pleuropulmonary variant of the adult-type pulmonary blastoma.

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  • 1Department of Pathology, Red Cross Children's Hospital, Cape, South Africa.


Two fatal childhood cases of the rare pulmonary blastoma are reported. One was associated with a congenital cystic adenomatoid malformation. Both neoplasms extended to involve visceral pleura and were entirely composed of blastemal and mesenchymal elements without recognizable neoplastic epithelial components. The mesenchymal component in both instances consisted of malignant rhabdomyoblasts, undifferentiated mesenchyme, and differentiated, apparently benign, cartilage. Review of the literature suggests that these features may be specific for the childhood forms of pulmonary blastoma. It is further suggested that pulmonary blastoma, malignant mesenchymoma of the lung, and primary pulmonary rhabdomyosarcoma may have a common pathogenetic origin.

[PubMed - indexed for MEDLINE]
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