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Microbes Infect. 2007 Jan;9(1):35-9. Epub 2006 Dec 15.

Shiga toxin binding in normal and inflamed human intestinal mucosa.

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  • 1Centre for Paediatric Gastroenterology, Royal Free & University College Medical School, Rowland Hill Street, London NW3 2PF, UK.


Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

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