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Exp Parasitol. 2007 May;116(1):83-7. Epub 2007 Jan 4.

Histone H1 regulates chromatin condensation in Leishmania parasites.

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  • 1Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066, Epalinges, Switzerland.


We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo.

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