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Trop Med Int Health. 2007 Jan;12(1):47-51.

Rapid diagnostic tests for dengue and leptospirosis: antibody detection is insensitive at presentation.

Author information

  • 1Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. alcohen1@cdc.gov

Abstract

OBJECTIVE:

To determine the performance of rapid diagnostic tests for dengue and leptospirosis that rely on detecting antibodies that may not be produced when patients present for medical treatment.

METHODS:

We prospectively enrolled 723 patients with undifferentiated febrile illness presenting to rural hospitals in northern and northeastern Thailand over a 1-year period. We evaluated rapid antibody detection diagnostic tests for dengue and leptospirosis on these patients.

RESULTS:

Sensitivity of the tests was low at the acute visit (7.6-21.5%). Sensitivity at the convalescent visit ranged from 25.8% to 81.5% and was significantly higher than at the acute visit for all tests (chi(2), P < 0.001).

CONCLUSIONS:

Low sensitivity of the rapid tests at presentation suggests that their utility in the acute phase of dengue and leptospirosis is limited.

PMID:
17207147
[PubMed - indexed for MEDLINE]
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