An unusual case of transitional cell carcinoma of renal pelvis presenting with brain metastases

Int Urol Nephrol. 2007;39(3):747-50. doi: 10.1007/s11255-006-9155-9. Epub 2007 Jan 4.

Abstract

We report a rare case, who had presented with a constellation of neurological symptoms (due to multiple brain metastases), but without any urological symptoms, to the department of neurosurgery. The patient was managed with gamma knife stereotactic radiosurgery for the metastatic lesions. During an evaluation for primary, he was found to be having transitional cell carcinoma (TCC) of right renal pelvis, for which palliative radical nephroureterectomy was performed, following which he received four cycles of paclitaxel and carboplatin chemotherapy. The patient is alive with stable disease at 22-months follow-up.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / surgery
  • Carboplatin / administration & dosage
  • Carcinoma, Transitional Cell / diagnosis
  • Carcinoma, Transitional Cell / secondary*
  • Carcinoma, Transitional Cell / surgery
  • Carcinoma, Transitional Cell / therapy
  • Combined Modality Therapy
  • Humans
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / drug therapy
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Kidney Pelvis*
  • Magnetic Resonance Imaging
  • Male
  • Paclitaxel / therapeutic use
  • Ureter / surgery

Substances

  • Carboplatin
  • Paclitaxel