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    South Med J. 2006 Nov;99(11):1235-42; quiz 1243-4, 1284.

    Irritable bowel syndrome: a practical review.

    Source

    GI Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

    Abstract

    The epidemiology and current understanding of the pathophysiology of irritable bowel syndrome is reviewed, beginning with a historical perspective. The roles of genetics, environment, allergy, infection and inflammation, bacterial overgrowth, hormones and motility abnormalities are discussed. Using the current evidence-based literature, the practical approach of diagnosis and treatment is outlined, including traditional modalities and newer therapeutic agents such as serotonin modulators.

    PMID:
    17195419
    [PubMed - indexed for MEDLINE]

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